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These changes, consisting principally of DNA methylation, histone modifications, and non-coding RNAs, maintain or modulate the initial impact of regulatory factors that recognize and associate with particular genomic sequences. Epigenetic modifications are manifest in all aspects of normal cellular differentiation and function, but they can also have damaging effects that result in pathologies such as cancer. Research is continuously uncovering the role of epigenetics in a variety of human disorders, providing new avenues for therapeutic interventions and advances in regenerative medicine.\r\n\r\nThis book's primary goal is to establish a framework that can be used to understand the basis of epigenetic regulation and to appreciate both its derivation from genetics and interdependence with genetic mechanisms. A further aim is to highlight the role played by the three-dimensional organization of the genetic material itself (the complex of DNA, histones and non-histone proteins referred to as chromatin), and its distribution within a functionally compartmentalized nucleus. This architectural organization of the genome plays a major role in the subsequent retrieval, interpretation, and execution of both genetic and epigenetic information.","brand":"None","offers":[{"title":"Hardcover","offer_id":46212333437138,"sku":"9780198831204","price":107.5,"currency_code":"CAD","in_stock":false},{"title":"Paperback","offer_id":46212333469906,"sku":"9780198831211","price":59.95,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0655\/8980\/5233\/files\/1_d0e941b4-cf7f-4b51-9451-f34c41455507.jpg?v=1764372301"},{"product_id":"advanced-genetic-counseling","title":"Advanced Genetic Counseling: Theory And Practice","description":"A CRITICAL NEW APPROACH FOR LEARNING AND THRIVING IN A FIELD OF CHANGE\r\n\r\nThe scope and responsibilities of today's genetic counselors exceed the reasonable capacity of any one educational resource. While the field's first-year curriculum may be relatively fixed, the landscape of what comes after that - a dizzying mix of practice, ethics, research design, and professional competencies - is increasingly broad. \r\n\r\nAdvanced Genetic Counseling offers an overdue extension of the field's core curriculum. From navigating ethical dilemmas and potential conflicts of interest to confronting the biases and patterns of thought that can limit counselors' interactions with clients, it prepares readers to face the profession's most challenging aspects with confidence.  \r\n\r\nDrawing on techniques from psychotherapy, social psychology, and health behavior, Advanced Genetic Counseling is an essential resource for trainees and mid-career professionals. It offers a roadmap not just for addressing client needs, but for the future of genetic counseling education.","brand":"None","offers":[{"title":"Paperback","offer_id":46213588189394,"sku":"9780190626426","price":76.95,"currency_code":"CAD","in_stock":true},{"title":"Kobo eBook","offer_id":46213588222162,"sku":"c9764e38-ac53-3162-b365-4b2c3b67e234","price":74.39,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0655\/8980\/5233\/files\/1_e59c5b5f-ac02-407e-b8e7-4bf729f8e742.jpg?v=1762359235"},{"product_id":"bone-dysplasias","title":"Bone Dysplasias: An Atlas of Genetic Disorders of Skeletal Development","description":"The definitive guide to genetic bone disorders, now revised and expanded with glossy photographs and radiographs.\r\n\r\nThis updated and expanded fourth edition of Bone Dysplasias presents age-related radiographs, photographs and clinical guidelines for more than 250 rare constitutional skeletal diseases. Focusing on diagnostically essential imaging and clinical features, each chapter is supplemented with prognostic and therapeutic information, a guide to differential diagnoses, and a short list of the most relevant publications. \r\n\r\nOrganized in accordance with the most recent International Nosology and Classification of Genetic Skeletal Disorders, this new Bone Dysplasias distills the insights of a small, world-class author team on diagnosis and clinical approaches to this most difficult class of disorders.","brand":"None","offers":[{"title":"Hardcover","offer_id":46212298768594,"sku":"9780190626655","price":356.95,"currency_code":"CAD","in_stock":true},{"title":"Kobo eBook","offer_id":46212298801362,"sku":"89ae962a-bd09-3b68-a936-2b16ce0e0b74","price":364.79,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0655\/8980\/5233\/files\/1_647a3c27-e96e-49f2-9d17-6412b42176c3.jpg?v=1763033795"},{"product_id":"genetic-counseling","title":"Genetic Counseling: Clinical Practice and Ethical Considerations","description":"Genetic counselors advise patients and families affected by or at risk of genetic disorders. They educate them about inheritance, diseases, and screening tests, interpret medical histories and test results, and help families cope with diagnoses and make informed medical decisions. The profession is rapidly evolving and is poised to play an increasingly important role in society as genome sequencing becomes routine clinical practice.\r\n\r\nThis collection from Cold Spring Harbor Perspectives in Medicine captures the current state of genetic counseling and examines the changing roles of genetic counselors in the genomic age. The contributors discuss the range of genetics-related needs people bring to counselors, existing and emerging technologies for genetic testing, challenges related to the abundance of recent discoveries about genetic diseases, the ways in which genetic counseling is integrated into modern medicine, and the expanding roles of genetic counselors beyond the clinical setting. The current and evolving practices in different counseling subspecialties, including infertility, prenatal care, pediatrics, cardiology, neurology, psychiatry, and cancer, are also covered.\r\n\r\nOther topics in the volume include ethical, legal, and social issues (e.g., genetic testing of minors, genetic discrimination, and obtaining informed consent for genomic testing), as well as the future of the profession. The volume is therefore an essential read for practicing genetic counselors, as well as all biomedical scientists and health professionals dedicated to using genetic and genomic information to improve the lives of individuals and their families.","brand":"None","offers":[{"title":"Paperback","offer_id":46214355779794,"sku":"9781621823964","price":86.95,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0655\/8980\/5233\/files\/1_532d5608-dd92-47e8-a8b2-02342166835f.jpg?v=1762836003"},{"product_id":"methods-for-genetic-risk-assessment","title":"Methods for Genetic Risk Assessment","description":"\u003cp\u003eGenetic disease contributes to a major portion of our health care costs. While most of the human genetic burden is transmitted from generation to generation, environmental chemicals capable of reacting with germ cell DNA could produce new mutations, resulting in an even greater genetic liability for the next generation. The potential impact of environmental mutagens on the health and viability of other living things is important to consider as well. Methods for Genetic Risk Assessment features contributions from international experts to provide a comprehensive review of the current status of genetic risk assessment. You'll learn about various methods and strategies for when and how to conduct genetic risk assessments on human populations. You will also learn about the potential effects of environmental genotoxins on nonhuman organisms.\u003c\/p\u003e","brand":"None","offers":[{"title":"Kobo eBook","offer_id":46216721334482,"sku":"b897db24-ee44-369b-9f68-ecc0db557c7e","price":645.87,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0655\/8980\/5233\/files\/image_40b5dde4-cabc-4d61-a17f-ad2e48b22fd6.jpg?v=1762381579"}],"url":"https:\/\/www.indigo.ca\/collections\/genetics.oembed","provider":"Indigo","version":"1.0","type":"link"}