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All major economies confront similar issues: \"demand-side\" growth in the care of aging populations in the face of \"supply-side\" resource constraints driven by ever-increasing costs of providing such care.  While cultural, historical, and political differences among nations will yield different solutions, healthcare leaders across the globe must deal with ever-increasing uncertainty as to the scope and speed of their healthcare systems' evolution.  The magnitude of these challenges calls for fundamental change to address inherent problems in the healthcare system and ensure sustainable access to healthcare for generations to come. 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