{"product_id":"some-chemicals-that-cause-tumours-of-the-kidney-or-urinary-bladder-in-rodents-and-some-other-substances","title":"Some Chemicals that Cause Tumours of the Kidney or Urinary Bladder in Rodents and Some Other Substances","description":"Evaluates the carcinogenic risk to humans posed by 20 individual compounds and three groups of compounds (cyclamates, saccharin and its salts, and nitrilotriacetic acid and its salts) that are known to induce tumours of the kidney or urinary bladder in rodents. As data on cancer in humans were judged inadequate for all compounds and groups of compounds the evaluations draw on recent guidelines for determining whether the mechanisms by which a chemical exerts its carcinogenic effects in rodents are relevant to humans. Evaluations also draw on findings from studies of metabolic fate toxic effects reproductive and developmental effects and genetic and related effects. \u003cbr\u003e\u003cbr some=\"\" of=\"\" the=\"\" compounds=\"\" covered=\"\" in=\"\" volume=\"\" are=\"\" widely=\"\" used=\"\" as=\"\" chemical=\"\" intermediates pesticides artificial=\"\" sweeteners=\"\" and=\"\" food=\"\" additives.=\"\" also=\"\" includes=\"\" evaluations=\"\" analgesic=\"\" antipyretic=\"\" paracetamol=\"\" several=\"\" naturally=\"\" occurring=\"\" substances=\"\" food.=\"\" all=\"\" but=\"\" two=\"\" methyl=\"\" tert-butyl=\"\" ether were=\"\" evaluated=\"\" previous=\"\" iarc=\"\" monographs.=\"\" re-evaluations=\"\" made=\"\" light=\"\" both=\"\" new=\"\" studies=\"\" a=\"\" growing=\"\" body=\"\" evidence=\"\" concerning=\"\" certain=\"\" pathological=\"\" processes=\"\" that=\"\" lead=\"\" to=\"\" tumour=\"\" development=\"\" kidney=\"\" urinary=\"\" bladder=\"\" rats=\"\" exposed=\"\" chemicals.=\"\"\u003e\u003cbr\u003e\u003cbr eight=\"\" compounds=\"\" were=\"\" classified=\"\" as=\"\" possibly=\"\" carcinogenic=\"\" to=\"\" ortho-anisidine chloroform chlorothalonil para-dichlorobenzene hexachloroethane nitrilotriacetic=\"\" acid=\"\" and=\"\" its=\"\" salts sodium=\"\" ortho-phenylphenate=\"\" potassium=\"\" bromate.=\"\" the=\"\" remaining=\"\" substances=\"\" could=\"\" not=\"\" be=\"\" on=\"\" basis=\"\" of=\"\" available=\"\" humans:=\"\"\u003e\u0026lt;\u0026gt;\u003cbr\u003e\u003ci\u003eSome Chemicals that Cause Tumors of the Kidney or Urinary Bladder in Rodents and Some Other Substances\u003c\/i\u003e","brand":"None","offers":[{"title":"Couverture souple","offer_id":46591911002322,"sku":"9789283212737","price":96.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0655\/8980\/5233\/files\/1_d63f6fa3-cf6b-4705-b6da-2634b2f8a688.jpg?v=1762967438","url":"https:\/\/www.indigo.ca\/fr\/products\/some-chemicals-that-cause-tumours-of-the-kidney-or-urinary-bladder-in-rodents-and-some-other-substances","provider":"Indigo","version":"1.0","type":"link"}