{"product_id":"developmental-oncology-principles-and-therapy-of-cancers-of-children-and-young-adults","title":"Developmental Oncology: Principles and therapy of cancers of children and young adults","description":"\u003cfont face=\"[Font[__TEXT_FONT_INDEX]]\" size=\"-1\"\u003e\u003cp\u003eA variety of cancers\r\n affect children and young adults, including leukemias, sarcomas, and \r\ntumors of the nervous system. These are caused by errors that occur \r\nduring development and arise in specific populations of cells that \r\naccumulate somatic mutations in early life.\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e  \u003cp\u003eWritten and edited by experts in the field, this collection from \u003cem\u003eCold Spring Harbor Perspectives in Medicine\u003c\/em\u003e\r\n provides a comprehensive review of our understanding of cancers that \r\noccur during childhood and in young adults, the mechanisms underlying \r\ntheir appearance, and current and future treatment strategies. Recent \r\ndiscoveries show these young-onset cancers are fundamentally \r\ndevelopmental in origin. The contributors review how developmental \r\nprocesses in the growing body generate cell states that are susceptible \r\nto tumorigenesis in particular types of cells. They discuss the bases \r\nfor genetic predisposition, endogenous and exogenous somatic mutational \r\nprocesses, epigenetic regulation, and the influence of the immune and \r\ntissue microenvironments.\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e   \u003cp\u003eIn addition, the authors examine the \r\nmultiple therapeutic approaches used to target young-onset cancers, such\r\n as combination treatments and immunologic, metabolic, and cellular \r\ntherapies. Cancer surveillance is also covered, as well as the unique \r\nchallenges of pediatric cancer drug development. The volume will \r\ntherefore be an essential reference for cancer biologists, practicing \r\noncologists, and those interested in how we can drive progress in cancer\r\n treatment.\u003c\/p\u003e\u003c\/font\u003e","brand":"None","offers":[{"title":"Hardcover","offer_id":46335808536786,"sku":"9781621825050","price":102.95,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0655\/8980\/5233\/files\/1_b157c4d4-46ed-4633-be8f-dd8a55767c15.jpg?v=1762857845","url":"https:\/\/www.indigo.ca\/products\/developmental-oncology-principles-and-therapy-of-cancers-of-children-and-young-adults","provider":"Indigo","version":"1.0","type":"link"}