{"product_id":"g-protein-methods-and-protocols-1","title":"G Protein Methods and Protocols: Role of G Proteins in Psychiatric and Neurological Disorders","description":"The G proteins are a family of structurally homologous, plasma membrane-associated guanine-nucleotide-binding proteins. These proteins play an integral role in the tra- duction of extracellular signals through second messenger systems. As such, G proteins affect a wide variety of intra cellular biochemical reactions by regulating the concent- tion of second messengers in cells. G proteins are heterotrimeric, consisting of a, p, and y polypeptide chains, with G protein specificity largely det- mined by the a-subunit, Molecular cloning of G protein s- units has revealed 23 distinct a-subunits, encoded by 17 different genes. Based on functional measures, G proteins are generally classified into three major categories: the G, family, which is stimulatory for adenylyl cyclase; the G, f- ily, which is inhibitory for adenylyl cyclase; and the G, f- ily, which stimulates phospholipases (Birnbaumer and Birnbaumer, 1995). Alternatively, on the basis of sequence homology, G proteins can be subdivided into four cate- ries: G,, G,, G,, and G12.","brand":"None","offers":[{"title":"Hardcover","offer_id":46393893421266,"sku":"9780896034907","price":248.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0655\/8980\/5233\/files\/1_dae39d6d-7cfa-4ce4-9694-701fede4eb23.jpg?v=1763410969","url":"https:\/\/www.indigo.ca\/products\/g-protein-methods-and-protocols-1","provider":"Indigo","version":"1.0","type":"link"}