{"product_id":"pharmaceutical-drugs","title":"Pharmaceutical Drugs","description":"Reports the deliberations of a working group convened to evaluate the carcinogenic risk to humans posed by the therapeutic use of 15 pharmaceutical drugs. The volume features separate monographs on five antineoplastic agents, four antimicrobial agents, two diuretics, ciclosporin (an immunosuppressant), cimetidine (used in the treatment of gastric and duodenal ulcers), paracetamol (a popular analgesic and antipyretic drug), and dantron (a laxative). Drugs were selected for inclusion on the basis of published data suggesting carcinogenic effects in experimental animals or in human patients treated with the drug. \u003cbr\u003e\u003cbr the=\"\" working=\"\" group=\"\" identified=\"\" two=\"\" of=\"\" drugs=\"\" ciclosporin=\"\" and=\"\" thiotepa=\"\" as=\"\" human=\"\" carcinogens.=\"\" an=\"\" immunosuppressant is=\"\" widely=\"\" used=\"\" in=\"\" prevention=\"\" treatment=\"\" graft-versus-host=\"\" reactions=\"\" bone-marrow=\"\" transplantation=\"\" to=\"\" prevent=\"\" rejection=\"\" kidney heart liver=\"\" transplants.=\"\" often=\"\" given=\"\" transplant=\"\" recipients=\"\" for=\"\" several=\"\" months has=\"\" been=\"\" linked=\"\" a=\"\" remarkably=\"\" high=\"\" occurrence=\"\" lymphomas found=\"\" predominantly=\"\" gastrointestinal=\"\" tract well=\"\" skin=\"\" cancer=\"\" kaposi sarcoma.=\"\" carcinogenicity=\"\" cytostatic=\"\" agent=\"\" malignant=\"\" solid=\"\" tumours clearly=\"\" demonstrated=\"\" both=\"\" experimental=\"\" animals=\"\" patients where=\"\" with=\"\" drug=\"\" development=\"\" leukaemia.=\"\"\u003e\u003cbr\u003e\u003cbr azacitidine chloramphenicol and=\"\" chlorozotocin=\"\" were=\"\" judged=\"\" to=\"\" be=\"\" probably=\"\" carcinogenic=\"\" humans while=\"\" dantron=\"\" trichlormethine=\"\" identified=\"\" as=\"\" possible=\"\" human=\"\" carcinogens.=\"\" the=\"\" remaining=\"\" substances=\"\" could=\"\" not=\"\" classified=\"\" on=\"\" basis=\"\" of=\"\" currently=\"\" available=\"\" evidence.=\"\" experts=\"\" also=\"\" noted=\"\" that=\"\" long-term=\"\" experiments=\"\" with=\"\" paracetamol nitrofurantoin nitrofural=\"\" have=\"\" shown=\"\" reductions=\"\" in=\"\" tumour=\"\" incidence=\"\" at=\"\" some=\"\" sites=\"\" animal=\"\" species.=\"\"\u003e\u003cbr azacitidine chloramphenicol and=\"\" chlorozotocin=\"\" were=\"\" judged=\"\" to=\"\" be=\"\" probably=\"\" carcinogenic=\"\" humans while=\"\" dantron=\"\" trichlormethine=\"\" identified=\"\" as=\"\" possible=\"\" human=\"\" carcinogens.=\"\" the=\"\" remaining=\"\" substances=\"\" could=\"\" not=\"\" classified=\"\" on=\"\" basis=\"\" of=\"\" currently=\"\" available=\"\" evidence.=\"\" experts=\"\" also=\"\" noted=\"\" that=\"\" long-term=\"\" experiments=\"\" with=\"\" paracetamol nitrofurantoin nitrofural=\"\" have=\"\" shown=\"\" reductions=\"\" in=\"\" tumour=\"\" incidence=\"\" at=\"\" some=\"\" sites=\"\" animal=\"\" species.=\"\"\u003e","brand":"None","offers":[{"title":"Paperback","offer_id":46591935316178,"sku":"9789283212508","price":96.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0655\/8980\/5233\/files\/1_ec271ed0-f523-4a7d-82e6-9fc7bb1ce53d.jpg?v=1762967437","url":"https:\/\/www.indigo.ca\/products\/pharmaceutical-drugs","provider":"Indigo","version":"1.0","type":"link"}