Dr. Cyrus Mills returns to his hometown after inheriting his father's failing veterinary practice. Cyrus intends to sell the practice and get out of town as fast as he can, but when his first patient—a down-on-her-luck golden retriever named Frieda Fuzzypaws—wags her way through the door, life suddenly gets complicated. With the help of a black Labrador gifted in the art of swallowing underwear, a Persian cat determined to expose her owner's lover as a gold digger, and the allure of a feisty, pretty waitress from the local diner, Cyrus gets caught up in a new community and its endearing residents, both human and animal. Sensing he may have misjudged the past, he begins to realize it's not just his patients that need healing. The Patron Saint of Lost Dogs is a winsome tale of new beginnings, forgiveness, and the joy of finding your way home.