Diet, Drugs, and Dopamine: The New Science of Achieving a Healthy Weight

David A. Kessler
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Diet, Drugs, and Dopamine: The New Science of Achieving a Healthy Weight

David A. Kessler
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Overview

400 PAGESENGLISH

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"In Diet, Drugs, and Dopamine, former FDA Commissioner David A. Kessler offers a comprehensive guide to weight loss . . . [and] urges us to recognize that obesity is a chronic condition that needs to be treated as such.” Los Angeles Times

"Highly readable and persuasive . . . A deep scientific understanding of the biological mechanisms involved, a former regulator’s pragmatism and a compassion born of personal experience make this an important contribution to the literature."
Financial Times

“A timely and ambitious book that tackles the obesity epidemic with a rare blend of scientific rigor, policy insight, and personal candor . . . Kessler brings decades of experience to bear on one of the most pressing public health crises of our time.”
—Medium.com

"Who could be better suited and more trustworthy than former FDA commissioner Dr. David A. Kessler to doggedly sort through the scientific evidence, cut through the hype, and bring us to a better understanding of our own body weight? Diet, Drugs, and Dopamine is eye-opening, beautifully crafted, full of practical insights, and a great read."
—Abraham Verghese, New York Times bestselling author of The Covenant of Water

"A beautifully rendered and illuminating exploration of the disease of obesity that will change not only how we understand our health but also how we understand one another."
—Siddhartha Mukherjee, MD, New York Times bestselling author of The Emperor of All Maladies

"A brilliant and incisive examination of one of our country's most vexing health challenges. Dr. Kessler's sharp scientific analysis cuts through the fog of confusion surrounding weight loss and offers a practical, sustainable pathway to better health. It is no surprise he is one of the great medical and public health leaders of our time."
—Vivek H. Murthy, MD, 19th and 21st Surgeon General of the United States and New York Times bestselling author of Together

Diet, Drugs, and Dopamine is a tour de force and reflects a clarity of thinking on many controversial issues from food restricting to intuitive eating, body positivity to toxic fat, and GLP-1 agonists as a possible revolutionary tool to combat obesity. There’s even a section on menopause! This book is the definitive scientific source on food addiction."
—Anna Lembke, MD, New York Times bestselling author of Dopamine Nation

"Dr. Kessler brilliantly walks the tightrope between the hype and the criticism around the new weight loss drugs—weaving personal stories with superbly accessible science. An important and illuminating book."
—Chris van Tulleken, New York Times bestselling author of Ultra-Processed People

“Dr. Kessler forensically dissects the weighty topic of obesity for all to understand. This is fascinating and essential reading for all.”
—VADM (Ret) Richard Carmona, MD, MPH, FACS, 17th Surgeon General of the United States

  • Published date: Dec 01, 2026
  • Language: English
  • No. of Pages: 400
  • Publisher: Flatiron Books
  • ISBN: 9781250381699
  • Dimensions: 5.38" W x 1.0" L x 8.25" H
David. A. Kessler, MD, served as chief science officer of the White House COVID-19 Response Team under President Joe Biden and previously served as commissioner of the US Food and Drug Administration under Presidents George H.W. Bush and Bill Clinton. He is the author of the New York Times bestsellers The End of Overeating and Capture as well as Fast Carbs, Slow Carbs and A Question of Intent. Dr. Kessler is a pediatrician and has been the dean of the medical schools at Yale and the University of California, San Francisco. He is a graduate of Amherst College, the University of Chicago Law School, and Harvard Medical School.

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