This book constitutes the proceedings of the First Conference of the Spanish Society of Artificial Intelligence in Biomedicine, CIABiomed 2025, held in Seville, Spain, during October 23&24, 2025.

The 38 full papers presented together with 9 short papers were carefully reviewed and selected from 55 submissions. They are organized in topical sections as follows: Explainable and interpretable AI in clinical and biomedical contexts; Ethics, privacy and security in AI applications in the healthcare; AI-based clinical decision support systems;Biomedical signal processing;Natural language processing (NLP) in biomedicine; Medical image processing and computer vision in clinical environments;Prediction of protein structures and molecular interactions with AI techniques; AI for multi-omic integration and analysis of heterogeneous biomedical data; Predictive modelling and personalised medicine using artificial intelligence.