In this issue ofMedical Clinics of North America, guest editor Dr. Stephanie K. Mueller brings her considerable expertise to the topic ofCare Transitions . Top experts discuss best practices, challenges, and innovations in patient care transitions across different healthcare settings, providing insights into evidence-based strategies for reducing readmissions, enhancing medication safety, engaging patients and families, and addressing social determinants that impact transitions of care. This issue also examines the role of technology, policy initiatives, and interdisciplinary collaboration in improving continuity of care.