For over half a century, the CDC Yellow Book has been a trusted resource, providing international travelers and clinicians with expert guidance for safe and healthy travel abroad. Along with disease-specific prevention and treatment recommendations, this comprehensive reference text provides readers with the background and context needed to understand and address health threats associated with all types of international travel. FEATURED IN THIS EDITION: · Precautions for international travelers during the coronavirus disease 2019 (COVID-19) pandemic, including links to updated information on related CDC and US government websites · Updates on practicing travel medicine in a virtual environment · New standalone vaccine tables for bacterial and viral diseases with links to the relevant Advisory Committee on Immunization Practices and US FDA websites · Safe international travel with pets and service animals · Advice for obtaining healthcare abroad including guidance on different types of travel insurance · Guidelines for self-treating common travel conditions including altitude illness, jet lag, motion sickness, and travelers' diarrhea · Detailed maps showing the distribution of travel-associated infections and diseases, including dengue and meningococcal meningitis · Country-specific mosquito avoidance, yellow fever vaccine, and malaria prevention recommendations · Food and drink precautions, plus updated water-disinfection techniques · Expanded content on safe international travel for specific groups including: LGBTQ+ individuals, highly allergic travelers, travelers with substance use issues, and medical tourists · Specialized recommendations for non-leisure travelers, study abroad, work-related travel, and travel to mass gatherings · Health insights for 14 popular destinations and itineraries in Africa and the Middle East, the Americas and the Caribbean, and Asia · Considerations for newly arrived adoptees, immigrants, and refugees