Alex Horsley, MA, MBChB, MRCP, PhD. NIHR, is Clinician Scientist at the University of Manchester and Honorary Consultant at the Manchester Adult CF Centre. Dr Horsley graduated from Cambridge and Edinburgh Universities and finished his respiratory training in Leeds and Edinburgh. He completed a PhD on lung physiology and lung clearance index at Edinburgh University with the CF Gene Therapy Consortium and has published and spoken on this widely. His research focuses on the development of early change in the CF lung, lung physiology technologies and the application of these to clinical practice. Dr Steve Cunningham is Consultant Respiratory Paediatrician at the Royal Hospital for Sick Children, Edinburgh, UK. Steve trained in Respiratory Paediatrics in Edinburgh, Great Ormond Street, London, and Sydney, Australia. He has previously published on models for Retinopathy of Prematurity, but is now more active within the United Kingdom Cystic Fibrosis Gene Therapy Consortium assessing clinical indicators of disease as outcome factors. In addition, Steve has a focus on the role of oxygen as a therapeutic agent in bronchiolitis. Steve is Chair of the Scottish Intercollegiate Guideline Network (SIGN91) Bronchiolitis Guideline, and also a contributing member to the Pharmacology section of the SIGN/BTS Living Asthma Guideline, and the British Thoracic Society Non-CF Bronchiectasis Guideline. He is also Chair of the Asthma UK Scottish Advisory Group. Dr Alastair Innes, University of Edinburgh. Dr Alastair Innes is Clinical Director of Respiratory Medicine for NHS Lothian and Honorary Reader in Respiratory Medicine at the University of Edinburgh. As a member of the Strategy Group, he heads the clinical part of the CFGT research team in Edinburgh. Alastair qualified in Edinburgh, and trained in Newcastle, London and Los Angeles before returning to a consultant post at the Western General Hospital in Edinburgh. He has worked in Adult Cystic Fibrosis care for 18 years, during which time he was involved in initial trials of nasal CF gene therapy in Edinburgh. Alastair's principal research interests are in novel clinical physiological measurements of airways disease, and their use to monitor disease processes and response to therapy.