Interstitial lesions occurred in two forms. First, in six cases an acute interstitial myocarditis, characterized by a large number of plasma cells between the muscle fibers, was found. Lymphoid cells were occasionally seen, but polymorphonuclear leukocytes were rare. This condition may or may not be accompanied by degeneration of the muscle fibers. The accumulations were sometimes circumscribed and sometimes diffuse. This condition is analogous to the acute interstitial, non-suppurative nephritis of the kidney. The average duration of this condition was ten days. The second form of myocarditis was more chronic in its character and evidently secondary to degeneration. The interstitial tissue was swollen and infiltrated with large cells of an endothelial char acter, with considerable formation, in some cases, of connective tissue. The average duration of this condition was seventeen days.

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