The problems of people with disabilities are determined by the dynamics of interactions between them and the social environment in which they live. Therefore, the bio-psycho-socio-spiritual model of health is linked to the civilian model, accentuating the active participation in the social life of a particular community. The convergence of these models is present in the transdisciplinary content of the publication, which examines the quality of life of pupils in inclusive education in the Central European region. The authors identified specific limits and possibilities of the educational environment and its impact on the quality of life of children with disabilities. They explained the evidence-based practice and enhanced the competency-based approach to the persons involved in education, their relatives and multidisciplinary school teams.