Tissue engineering is a medical engineering discipline that is concerned with in-vitro engineering of tissues and organs. It draws from multiple fields, including materials science, cell and molecular biology, transplantation, and mechanical engineering. It combines suitable cells, derivative materials, and biochemical factors to aid and increase repair and regeneration in deficient and injured tissues. Biologic scaffolds are support structures designed to facilitate cellular growth and proliferation in patients who have undergone implantation procedures. They are biocompatible, biodegradable, and bioactive materials used to repair and regenerate different tissues such as skin, bone, cartilage, nerves, liver, and muscles. Stem cells are cells that have the potential to develop into several distinct types of cells found in the body. They serve as a repair system for the body. Stem cell therapy, also called to as regenerative medicine, uses stem cells to promote the repair response of diseased, dysfunctional, or injured tissues. This book provides comprehensive insights into the field of stem cell biology and tissue engineering. It will help the readers in keeping pace with the rapid changes in this field.