Leo Liu's research interests include poromechanics, multiphysics, Artificial Intelligence (AI), and cyber-physical systems. The scope covers both traditional civil engineering applications, such as unsaturated soil mechanics, geohazards, energy geotechnics, and more interdisciplinary innovations, such as intelligent geosystems (for smart cities), system resilience against disaster and weather, and "big data" solutions for intelligent geosystems and transportation systems. His research has many direct applications in infrastructure safety, energy resources, environment protection, and advanced materials.