Book Review 1:

"The world is aging! Each year life expectancy increases in many countries. The age pyramid lost the thin peak represented by elderly, and its wide base of newborns, transforming itself in almost an upside-down pyramid. With the accumulation of aged people, also comes a health service overload, so the understood of changes in an organism related with increasing of age are really an essential discussion. This book brings this topic with details. A dense and complex text, passing through every main mechanism of an organism age-related changes. Each chapter discuss carefully the complex and, at the same time, dynamic alterations that come with senescence. Each one of these alterations are also described by the mechanisms involved, and the impact of the change. These changes can affect immune defense, vaccine responses, organ functioning, and even simple aspects as digestion and nutrients absorption. Besides that, the topics of immunotherapy, which is little explored on age research area, represents on the book an interesting discussion about applications and some problems. But nowadays think about alternatives to underwent elderly problems by using immune mediated treatment are the real future to get around the health overload problem that is being occasioned by world aging. Knowing this kind of information makes us, as humans start to think about our lifestyle and habits, and possible modifications to improve quality of life. And as researchers, the content of the book is important to impulse more discovers, researches and data about interventions and treatments to reduce some side effect of this biological process called Aging." -- Juliana Ruiz Fernandes, biologist (Centro Universitário São Camilo, São Paulo, Brazil); Master and PhD in Sciences (Faculdade de Medicina da Universidade de São Paulo); Currently PosDoc in Immunossenescence by Faculdade de Medicina da Universidade de São Paulo.

Book Review 2:

"In the One Health era the book "Immunotherapy in bioregenerative medicine: The brief review and highlights" represents an obligatory reading topic, mostly for physicians and the other health professionals which would improve the way they practice medicine and related topics. It is important to have a more holistic view to treat patients to make them recover from disease or to keep them healthy. Immunotherapy is a type of treatment that helps our immune system to maintain our physiology and homeostasis and to fight against infectious or neoplastic diseases using immunobiologicals. The seriousness of immunobiological production to human use as immunotherapy in humans follows strict rules and laws making them expensive and inaccessible when we think of public health services. However, the cost of manufacturing immunobiological needs to be improved as science development and innovation are getting better in the majority of countries......" -- Paula Ordonhez Rigato Head of Immunobiology and Biomarkers Laboratory, Center of Immunology, Institute Adolfo Lutz (Laboratory of Public Health), São Paulo, Brazil Biomedical Profissional (University of Mogi das Cruzes, Sao Paulo, Brazil); Specialist in Clinical Pathology (University Federal of São Paulo State - UNIFESP); Specialist in Immunodeficiencies (School of Medicine University of São Paulo); Master and PhD in Immunology (Institute of Biomedical Sciences of University of São Paulo); PosDoc in Immunology and Vaccinology by UNIFESP, CEA-Fontanay-Aux-Roses-France and University of Sao Paulo), Scientific Researcher Leve V in Institute Adolfo Lutz.