For Ukraine, the signing of the Association Agreement and the DCFTA with the European Union in 2014 was an act of strategic geopolitical significance. Emblematic of the struggle to replace the Yanukovych regime at home and to resist attempts by Russia to deny its 'European choice', the Association Agreement is a defiant statement of Ukraine's determination to become an independent democratic state. The purpose of this Handbook is to make the complex political, economic and legal content of the Association Agreement readily understandable. This third edition, published seven years since signature of after entry into force of the Agreement's implementation is substantially new in content, both updating how Ukraine has been implementing the Agreement, and introducing new dimensions (including the Green Deal, the Covid-19 pandemic, cyber security, and gender equality). The Handbook is also up to date in analysing Ukraine's the development of the Zelensky administration, with its unfinished agenda for cutting corruption and reforming the rule of law. Two teams of researchers from leading independent think tanks, CEPS in Brussels and the Institute for Economic Research and Policy Consulting (IER) in Kyiv, collaborated on this project, with the support of the Swedish International Development Agency (Sida). This Handbook is one of a trilogy examining similar Association Agreements made by the EU with Georgia and Moldova.