In this issue ofClinics in Perinatology, guest editor Dr. Lina Chalak brings her considerable expertise to the topic ofPerinatal Asphyxia: Moving the Needle . Top experts discuss current clinical information on perinatal asphyxia, giving perinatologists they guidance they need to improve outcomes in newborns, while looking at results from clinical trials, neuroimaging biomarkers, and low-resource settings.